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5 As shown in Table 1 (The Global Burden of Disease study 2017), 6 COPD attributed to active smoking, ambient particulate matter pollution, occupational particulate matter/gases/fumes, ambient ozone pollution, household air pollution from solid fuels, secondhand smoke, and lead exposure was responsible for about 3 -tocopherol and childhood asthma

Phase 2 detoxification is the critical step where these highly reactive intermediates are neutralized and prepared for safe excretion from the body

Numerous reports indicate an increased presence of reactive oxygen species (ROS) in DPN [47,48,49,50]

2b and Fig

Honow R, Laube N, Schneider A, Kessler T, Hesse